Glial tumors with neuronal differentiation

Abstract

Immunohistochemical studies for neuronal differentiation in glial tumors revealed subsets of tumors having both characteristics of glial and neuronal lineages. Glial tumors with neuronal differentiation can be observed with diverse phenotypes and histologic grades. The rosette-forming glioneuronal tumor of the fourth ventricle and papillary glioneuronal tumor have been newly classified as distinct disease entities. There are other candidates for classification, such as the glioneuronal tumor without pseudopapillary architecture, glioneuronal tumor with neuropil-like islands, and the malignant glioneuronal tumor. The clinical significance of these previously unclassified tumors should be confirmed.

Keywords: Glioneuronal tumor with neuropil-like islands; Glioneuronal tumors without pseudopapillary architecture; Malignant glioneuronal tumor; Neuronal differentiation; Papillary glioneuronal tumor; Rosette-forming glioneuronal tumor of the fourth ventricle.