Appraising the European randomized study of screening for prostate cancer: what do the results mean?
- PMID: 25432497
- PMCID: PMC4650457
- DOI: 10.4103/1008-682X.142131
Appraising the European randomized study of screening for prostate cancer: what do the results mean?
Abstract
The value of screening for prostate cancer has been a contentious issue within the medical literature for several decades. At the crux of the matter lies a judgment call of whether the potential benefits of screening, a reduction in prostate cancer and all-cause mortality, outweigh the limitations, overdiagnosis and overtreatment. The study by Schrφder et al. reports 9, 11 and 13-year follow-up data on men participating in the European randomized study of screening for prostate cancer (ERSPC). While the authors report a significant reduction in prostate cancer mortality, they conclude that potential harms associated with screening currently circumvent any recommendation for a population-based approach to screening for prostate cancer.
Comment on
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Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up.Lancet. 2014 Dec 6;384(9959):2027-35. doi: 10.1016/S0140-6736(14)60525-0. Epub 2014 Aug 6. Lancet. 2014. PMID: 25108889 Free PMC article. Clinical Trial.
References
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- Schröder FH, Roobol-Bouts M, Vis AN, van der Kwast T, Kranse R. Prostate-specific antigen-based early detection of prostate cancer - validation of screening without rectal examination. Urology. 2001;57:83–90. - PubMed
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