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Review
. 2015 Mar;46(1):1-4.
doi: 10.1007/s12029-014-9673-0.

Shifting paradigm in the management of anal canal carcinoma

Supriya Mallick  1 , Rony Benson, P K Julka, G K Rath
Affiliations
Review

Shifting paradigm in the management of anal canal carcinoma

Supriya Mallick et al. J Gastrointest Cancer. 2015 Mar.

Abstract

Background: Anal canal is the lower most part of the gastrointestinal tract harbouring 4 % of all gastrointestinal cancer. Most common treatment for anal canal carcinoma includes chemoradiotherapy.

Methodology: We reviewed the recent landmark trials to find a road map in the management of anal canal carcinoma.

Results: Concurrent chemoradiotherapy appears to be the most effective treatment schedule. Induction, as well as maintenance chemotherapy, has no definite role. Moderate dose radiation 50.4-54 Gy with concurrent mitomycin C (MMC) and 5-fluorouracil (5-FU) remains the standard. Split course is detrimental. Intensity-modulated radiotherapy and targeted drugs are investigated.

Conclusion: Combined modality therapy is the standard for anal canal carcinoma.

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