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. 2015 Jan 30;225(1-2):208-211.
doi: 10.1016/j.psychres.2014.11.007. Epub 2014 Nov 13.

Metabolic and inflammatory genes in schizophrenia

Kayla A Chase  1 , Cherise Rosen  1 , Hannah Gin  1 , Olivia Bjorkquist  1 , Benjamin Feiner  1 , Robert Marvin  1 , Sean Conrin  1 , Rajiv P Sharma  2
Affiliations

Metabolic and inflammatory genes in schizophrenia

Kayla A Chase et al. Psychiatry Res. .

Abstract

Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.

Keywords: Inflammation; Obesity; Schizophrenia.

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Conflict of interest statement

Conflict of interest statement: There are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Diagnosis, demographics and morphometrics of obesogenic and immunogenic genes. Significant results are obtained from multiple regressions with each gene of interest as the dependent variable and diagnosis, medication use (in CPZ units), age, BMI, sex, a previous diagnosis of diabetes, age of onset of psychotic symptoms and tobacco consumption as explanatory variables. (A) Increased PPARγ mRNA levels were seen in patients with schizophrenia when compared to normal controls. Patients with schizophrenia had significantly decreased levels of both PPARα (B) and C/EBPα (C) mRNA when compared to normal controls. Increased SREBP1 (D), IL-6 (E) and TNFα (F) mRNA levels were seen in patients with schizophrenia when compared to their normal control counterparts. PPARγ and IL-6 mRNA were also significantly increased in overweight participants (BMI≥25), as determined by multiple linear regression. *p<0.05, **p<0.01.
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References

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