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Comment
. 2014 Dec;16(12):1130-2.
doi: 10.1038/ncb3079.

Rsp5/Nedd4 clears cells of heat-damaged proteins

Thomas Sommer  1 , Annika Weber  1 , Ernst Jarosch  1
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Comment

Rsp5/Nedd4 clears cells of heat-damaged proteins

Thomas Sommer et al. Nat Cell Biol. 2014 Dec.

Abstract

Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.

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