. 2015 Oct:48:50-7.

doi: 10.1016/j.chiabu.2014.11.003. Epub 2014 Nov 27.

Maternal intimate partner violence exposure, child cortisol reactivity and child asthma

Megan H Bair-Merritt¹, Kristin Voegtline², Sharon R Ghazarian³, Douglas A Granger⁴, Clancy Blair⁵; Family Life Project Investigators; Sara B Johnson⁶

Collaborators, Affiliations

Collaborators

Family Life Project Investigators:
Lynne Vernon Feagans, Martha Cox, Clancy Blair, Peg Burchinal, Linda Burton, Keith Crnic, Ann Crouter, Patricia Garrett-Peters, Mark Greenberg, Stephanie Lanza, Roger Mills-Koonce, Debra Skinner, Emily Werner, Michael Willoughby

Affiliations

¹ Division of General Pediatrics, Boston Medical Center, 88 East Newton Street, Vose 305, Boston, MA 02118, USA.
² Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
³ Johns Hopkins School of Medicine, 200 North Wolfe Street, Division of General Pediatrics, Baltimore, MD 21287, USA.
⁴ Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, 550 East Orange Street, Tempe, AZ 85287, USA; School of Nursing, Johns Hopkins, 525 North Wolfe Street, Baltimore, MD 21205, USA; Department of Applied Psychology, New York University, 246 Greene Street, New York, NY 10003, USA.
⁵ Division of General Pediatrics, Boston Medical Center, 88 East Newton Street, Vose 305, Boston, MA 02118, USA; Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA; Johns Hopkins School of Medicine, 200 North Wolfe Street, Division of General Pediatrics, Baltimore, MD 21287, USA; Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, 550 East Orange Street, Tempe, AZ 85287, USA; School of Nursing, Johns Hopkins, 525 North Wolfe Street, Baltimore, MD 21205, USA; Department of Applied Psychology, New York University, 246 Greene Street, New York, NY 10003, USA.
⁶ Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA; Johns Hopkins School of Medicine, 200 North Wolfe Street, Division of General Pediatrics, Baltimore, MD 21287, USA.

PMID: 25435104
PMCID: PMC4446253
DOI: 10.1016/j.chiabu.2014.11.003

Maternal intimate partner violence exposure, child cortisol reactivity and child asthma

Megan H Bair-Merritt et al. Child Abuse Negl. 2015 Oct.

. 2015 Oct:48:50-7.

doi: 10.1016/j.chiabu.2014.11.003. Epub 2014 Nov 27.

Authors

Megan H Bair-Merritt¹, Kristin Voegtline², Sharon R Ghazarian³, Douglas A Granger⁴, Clancy Blair⁵; Family Life Project Investigators; Sara B Johnson⁶

Collaborators

Family Life Project Investigators:
Lynne Vernon Feagans, Martha Cox, Clancy Blair, Peg Burchinal, Linda Burton, Keith Crnic, Ann Crouter, Patricia Garrett-Peters, Mark Greenberg, Stephanie Lanza, Roger Mills-Koonce, Debra Skinner, Emily Werner, Michael Willoughby

Affiliations

¹ Division of General Pediatrics, Boston Medical Center, 88 East Newton Street, Vose 305, Boston, MA 02118, USA.
² Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
³ Johns Hopkins School of Medicine, 200 North Wolfe Street, Division of General Pediatrics, Baltimore, MD 21287, USA.
⁴ Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, 550 East Orange Street, Tempe, AZ 85287, USA; School of Nursing, Johns Hopkins, 525 North Wolfe Street, Baltimore, MD 21205, USA; Department of Applied Psychology, New York University, 246 Greene Street, New York, NY 10003, USA.
⁵ Division of General Pediatrics, Boston Medical Center, 88 East Newton Street, Vose 305, Boston, MA 02118, USA; Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA; Johns Hopkins School of Medicine, 200 North Wolfe Street, Division of General Pediatrics, Baltimore, MD 21287, USA; Institute for Interdisciplinary Salivary Bioscience Research, Arizona State University, 550 East Orange Street, Tempe, AZ 85287, USA; School of Nursing, Johns Hopkins, 525 North Wolfe Street, Baltimore, MD 21205, USA; Department of Applied Psychology, New York University, 246 Greene Street, New York, NY 10003, USA.
⁶ Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA; Johns Hopkins School of Medicine, 200 North Wolfe Street, Division of General Pediatrics, Baltimore, MD 21287, USA.

PMID: 25435104
PMCID: PMC4446253
DOI: 10.1016/j.chiabu.2014.11.003

Abstract

Psychosocial stressors like intimate partner violence (IPV) exposure are associated with increased risk of childhood asthma. Longitudinal studies have not investigated the role of hypothalamic-pituitary-adrenal (HPA) axis reactivity (and associated alterations in cortisol release) in the child IPV exposure-asthma association. We sought to investigate this association, and to assess whether this relationship differs by child HPA reactivity. This secondary analysis used longitudinal cohort data from the Family Life Project. Participants included 1,292 low-income children and mothers; maternal interview and child biomarker data, including maternal report of IPV and child asthma, and child salivary cortisol obtained with validated stress reactivity paradigms, were collected when the child was 7, 15, 24, 35, and 48 months. Using structural equation modeling, maternal IPV when the child was 7 months of age predicted subsequent reports of childhood asthma (B=0.18, p=.002). This association differed according to the child's HPA reactivity status, with IPV exposed children who were HPA reactors at 7 and 15 months of age--defined as a ≥10% increase in cortisol level twenty minutes post peak arousal during the challenge tasks and a raw increase of at least .02μg/dl--being significantly at risk for asthma (7 months: B=0.17, p=.02; 15 months: B=0.17, p=.02). Our findings provide support that children who are physiologically reactive are the most vulnerable to adverse health outcomes when faced with environmental stressors.

Keywords: Asthma; Cortisol; Intimate partner violence; Longitudinal.

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Conflict of interest statement

Disclosure: In the interest of full disclosure, DAG is founder and Chief Scientific and Strategy Advisor at Salimetrics LLC (Carlsbad, CA) and this relationship is managed by the policies of the committees on conflict of interest at the Johns Hopkins University School of Medicine and the Office for Research Integrity and Assurance at Arizona State University. The other authors have no relevant financial disclosures.

Conflicts of Interest: None of the authors have conflicts of interest to disclose

Figures

**Figure 1**
Associations between IPV and child asthma expression* *Figure depicts latent intercept and slope variables each constructed by 4 time points of data (7, 15, 24, 35 months). Loadings for intercepts (not shown) are all set so that the intercept models baseline levels (7 month) of IPV. Arrows leading to child asthma reports depict hypothesized associations between baseline (intercept) and growth (slope) of IPV with child asthma. *Note*: Stratified models with child cortisol reactivity not shown.

See this image and copyright information in PMC

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Maternal intimate partner violence exposure, child cortisol reactivity and child asthma

Collaborators

Affiliations

Maternal intimate partner violence exposure, child cortisol reactivity and child asthma

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical