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Review
. 2015 Feb;62(1):201-23.
doi: 10.1016/j.pcl.2014.09.014.

Retinoblastoma

Carlos Rodriguez-Galindo  1 , Darren B Orbach  2 , Deborah VanderVeen  3
Affiliations
Review

Retinoblastoma

Carlos Rodriguez-Galindo et al. Pediatr Clin North Am. 2015 Feb.

Abstract

Retinoblastoma is the most common neoplasm of the eye in childhood, and represents 3% of all childhood malignancies. Retinoblastoma is a cancer of the very young; two-thirds are diagnosed before 2 years of age and 95% before 5 years. Retinoblastoma presents in 2 distinct clinical forms: (1) a bilateral or multifocal, heritable form (25% of all cases), characterized by the presence of germline mutations of the RB1 gene; and (2) a unilateral or unifocal form (75% of all cases), 90% of which are nonhereditary. The treatment of retinoblastoma is multidisciplinary and is designed primarily to save life and preserve vision.

Keywords: Chemotherapy; Germline mutation; Retinoblastoma; Second malignant neoplasms.

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