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Review
. 2015 Feb;62(1):301-12.
doi: 10.1016/j.pcl.2014.09.018. Epub 2014 Oct 18.

Remaining challenges in childhood cancer and newer targeted therapeutics

Malcolm A Smith  1 , Gregory H Reaman  2
Affiliations
Review

Remaining challenges in childhood cancer and newer targeted therapeutics

Malcolm A Smith et al. Pediatr Clin North Am. 2015 Feb.

Abstract

Despite the enormously important and gratifying advances in cancer treatment outcomes for children with cancer, cancer remains the biggest cause of death from disease in children. Because the etiology and biology of cancers that occur in children differ dramatically from those that occur in adults, the immediate extrapolation of efficacy and safety of new cancer drugs to childhood cancer indications is not possible. We discuss factors that will play key roles in guiding pediatric oncologists as they select lines of research to pursue in their quest for more effective treatments for children with cancer.

Keywords: Innovative clinical trials; Pediatric cancer drug development; Personalized medicine; Preclinical testing; Targeted therapy.

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Figures

Figure 1
Figure 1
Patterns of mortality for children and adolescents < 15 years and 15–19 years for 2007–2010. ALL = acute lymphoblastic leukemia, AML = acute myeloid leukemia, Oth Leuk = other leukemia, NHL = non-Hodgkin lymphoma. Adapted from Smith MA, Altekruse SF, Adamson PC, Reaman GH, Seibel NL. Declining childhood and adolescent cancer mortality. Cancer. 2014;120(16):2497–2506; with permission.
See this image and copyright information in PMC

References

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