Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;9(1):381-386.
doi: 10.3892/ol.2014.2634. Epub 2014 Oct 24.

Tumor size predicts prognosis of head and neck synovial cell sarcoma

Alimujiang Wushou  1 , Xin-Chao Miao  2
Affiliations

Tumor size predicts prognosis of head and neck synovial cell sarcoma

Alimujiang Wushou et al. Oncol Lett. 2015 Jan.

Abstract

Head and neck synoviosarcoma (HNSS) is uncommon. To the best of our knowledge, the specific clinicopathological characteristics, treatment outcome and prognostic factors of HNSS were uninvestigated at the time of writing, so a meta-analysis was performed. An online data collection was carried out using PubMed and Google Scholar. Studies that reported primary HNSS and the treatment, follow-up time and outcome were chosen for the present study. In total, 93 cases from 26 studies were included for analysis. The study sample consisted of 55 males and 38 females and the median age was 32.1 years (range, 4-76 years). The median follow-up period was 62.1 months (range, 1-373 months). The tumor size was correlated with local recurrence and metastasis of HNSS, as well as with mortality (P=0.001, P<0.0001 and P<0.0001, respectively). The three-year, five-year and 10-year survival rates were 82.1, 80.4 and 78.2% for treatment with surgery alone, and 88.5, 85.5 and 82% for treatment with surgery plus radiotherapy, respectively. A significant tumor size-dependent difference was found between the overall survival (OS) rates (P<0.0001), as tumors that were >5.0 cm in diameter were associated with a worse OS rate (hazard ratio, 6.460; 95% confidence interval, 206-18.917; P=0.001). The tumor size was found to be an independent adverse prognostic factor for the OS of HNSS patients. In conclusion, surgical excision is a mainstream treatment of HNSS and post-operative adjuvant radiotherapy improves the OS rate of HNSS patients.

Keywords: head and neck; meta-analysis; outcome; synoviosarcoma; treatment.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram of the process of identifying and selecting studies for the analysis.
Figure 2
Figure 2
Overall survival rates of head and neck synoviosarcoma patients treated with three different treatment modalities.
Figure 3
Figure 3
Kaplan-Meier analysis for overall survival of head and neck synoviosarcoma patients depending on tumor size.
See this image and copyright information in PMC

References

    1. Gurney JG, Young JL, Jr, Roffers SD, et al. Soft tissue sarcomas. In: Gloeckler Ries LA, Smith MA, Gurney JG, Linet M, Tamra T, Young JL Jr, Bunin GR, editors. Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975–1995. National Cancer Institute, SEER program; Bethesda, MA, USA: 1999. pp. 111–123.
    1. Bergh P, Meis-Kindblom JM, Gherlinzoni F, et al. Synovial sarcoma: identification of low and high risk groups. Cancer. 1999;85:2596–2607. doi: 10.1002/(SICI)1097-0142(19990615)85:12<2596::AID-CNCR16>3.0.CO;2-K. - DOI - PubMed
    1. Ichinose H, Wickstrom JK, Hoerner HE, Derbes VL. The early clinical presentation of synovial sarcoma. Clin Orthop Relat Res. 1979:185–189. - PubMed
    1. Spillane AJ, A’Hern R, Judson IR, Fisher C, Thomas JM. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol. 2000;18:3794–3803. - PubMed
    1. Kawai A, Woodruff J, Healey JH, et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med. 1998;338:153–160. doi: 10.1056/NEJM199801153380303. - DOI - PubMed

LinkOut - more resources