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Multicenter Study
. 2014 Dec 1;9(12):e114166.
doi: 10.1371/journal.pone.0114166. eCollection 2014.

Self-reported body fat change in HIV-infected men is a marker of decline in physical health-related quality of life with aging, independent of co-morbidity

Kristine M Erlandson  1 , Sandra M Reynolds  2 , Christopher Cox  2 , Frank J Palella  3 , Mallory D Witt  4 , Lawrence A Kingsley  5 , Todd T Brown  6 , Michael Plankey  7
Affiliations
Multicenter Study

Self-reported body fat change in HIV-infected men is a marker of decline in physical health-related quality of life with aging, independent of co-morbidity

Kristine M Erlandson et al. PLoS One. .

Abstract

Objective: Self-perception of changes in body fat among HIV+ persons is associated with decreased health related quality of life in cross-sectional studies. The longitudinal impact of body fat changes on health related quality of life, while accounting for comorbidity and anatomic location or severity of body fat changes, is unknown.

Design: This was a longitudinal analysis of HIV+ and HIV- Multicenter AIDS Cohort Study (MACS) participants who completed questionnaires assessing self-perceived body fat changes (baseline visit) and a health related quality of life (Short Form-36) at baseline and then ≥5 years later.

Methods: Relationships between body fat changes and change in Short Form-36 Physical and Mental Component Summary scores were investigated using mixed-model regression.

Results: We studied 270 HIV+ and 247 HIV- men. At baseline, ≥50% of HIV+ men reported body fat changes; physical component but not mental component summary scores were lower among HIV+ men who reported moderate/severe leg or abdominal fat changes (p<0.05). At follow-up, physical component summary scores were significantly lower among men with face, leg, or abdominal fat changes compared to men without perceived fat changes (p<0.05). No significant changes were seen in mental component scores by fat change location or severity. In the final model, body fat changes at any site or severity were significant predictors of a decline in physical component summary score (p<0.05), independent of demographics or comorbidities. Mental component summary score was not associated with body fat changes, but higher mental component summary score was associated with increasing age and time.

Conclusions: Negative self-perceived body fat changes were associated with decline in physical health related quality of life, independent of comorbidities, and may be a marker of an increased risk for physical function decline with aging.

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Conflict of interest statement

Competing Interests: TTB serves on the board for EMD-Serono, Theratechnologies, and Merck; is a consultant for Gilead, ViiV Healthcare, and Abbvie; and has received research grants from Merck. FJP is on the Speakers' Bureau for Gilead Sciences, Merck, Bristol Myers Squibb, and Janssen.

Figures

Figure 1
Figure 1. Study design indicating the relationship between the time highly active antiretroviral therapy (HAART) was initiated, the baseline visit where the initial Short Form (SF)-36 health related quality of life (HR-QoL) questionnaire was completed, and the follow-up visit when the second questionnaire was completed.
Figure 2
Figure 2. CONSORT diagram of study participant enrollment for HIV+ and HIV- participants.
HAART, highly active antiretroviral therapy; HR-QoL, health related quality of life.
See this image and copyright information in PMC

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