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Review
. 2015 Jan 16;10(1):213-24.
doi: 10.1021/cb5007135. Epub 2014 Dec 26.

Bacterial histidine kinases as novel antibacterial drug targets

Agnieszka E Bem  1 , Nadya Velikova, M Teresa Pellicer, Peter van Baarlen, Alberto Marina, Jerry M Wells
Affiliations
Review

Bacterial histidine kinases as novel antibacterial drug targets

Agnieszka E Bem et al. ACS Chem Biol. .

Abstract

Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.

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