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Review
. 2014 Dec;28(6):1093-106.
doi: 10.1016/j.bpg.2014.09.005. Epub 2014 Sep 28.

Implementation of gastric cancer screening - the global experience

Mārcis Leja  1 , Weicheng You  2 , M Constanza Camargo  3 , Hiroshi Saito  4
Affiliations
Review

Implementation of gastric cancer screening - the global experience

Mārcis Leja et al. Best Pract Res Clin Gastroenterol. 2014 Dec.

Abstract

Gastric cancer (GC) is still an important global healthcare problem, and in absolute figures it is going to remain at the present level in foreseeable future. In general, survival of patients with GC is poor mainly due to advanced-stage diagnosis. Early-stage GC can be cured by endoscopic resection or less invasive surgical treatment. Unfortunately, there is no appropriate screening strategy available for global application. This article provides a description of established national and regional GC screening programs and the screening modalities used. This review also summarizes current approaches to develop cancer-screening biomarkers. Although candidates with initial promising results have been suggested, moving discovery into clinical practice is still a major challenge. Well-designed biomarker studies, with systematic validation steps, are needed to decrease the burden of this fatal disease.

Keywords: Biomarkers; Gastric cancer; Helicobacter pylori; Precancerous lesions; Screening.

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Conflict of interest statement

CONFLICT OF INTEREST

Nothing to declare

Figures

Figure 1
Figure 1
Potential prevention and control strategies of gastric cancer and the related premalignant lesions
See this image and copyright information in PMC

References

    1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet] Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocaniarcfr, accessed on 05/01/2014.
    1. Forman D, Sierra MS. The current and projected global burden of gastric cancer H pylori eradication as a strategy for prevention of gastric cancer. Lyon: IARC; 2014. In Press.
    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. - PubMed
    1. De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, et al. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE–5-a population-based study. Lancet Oncol. 2014;15:23–34. - PubMed
    1. Lui FH, Tuan B, Swenson SL, Wong RJ. Ethnic Disparities in Gastric Cancer Incidence and Survival in the USA: An Updated Analysis of 1992–2009 SEER Data. Dig Dis Sci. 2014 - PubMed

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