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Review
. 2014 Dec;34(4):699-710.
doi: 10.1016/j.cll.2014.08.002. Epub 2014 Sep 15.

The interrelationships of the gut microbiome and inflammation in colorectal carcinogenesis

Margaret Cho  1 , Janell Carter  1 , Saul Harari  1 , Zhiheng Pei  2
Affiliations
Review

The interrelationships of the gut microbiome and inflammation in colorectal carcinogenesis

Margaret Cho et al. Clin Lab Med. 2014 Dec.

Abstract

The cause of colorectal cancer (CRC) is multifactorial, with genetic, molecular, inflammatory, and environmental risk factors. Recently, the gut microbiota has been recognized as a new environmental contributor to CRC in both animal models and human studies. An additional interplay of the gut microbiome with inflammation is also evident in studies that have shown that inflammation alone or the presence of bacteria/bacterial metabolites alone is not enough to promote tumorigenesis. Rather, complex interrelationships with the gut microbiome, inflammation, genetics, and other environmental factors are evident in progression of colorectal tumors.

Keywords: Carcinogenesis; Colorectal cancer; Gut microbiome; Inflammation.

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Figures

Figure 1
Figure 1
Overview of factors leading to colorectal carcinogenesis. The microbiome interacts with inflammatory mechanisms as well as dietary factors in progression of tumorigenesis.
See this image and copyright information in PMC

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