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Review
. 2014 Dec;34(4):763-70.
doi: 10.1016/j.cll.2014.08.003. Epub 2014 Sep 15.

The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease

Hu Jianzhong  1
Affiliations
Review

The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease

Hu Jianzhong. Clin Lab Med. 2014 Dec.

Abstract

Extensive genetic studies have identified more than 140 loci predisposing to Crohn disease (CD). Several major CD susceptibility genes have been shown to impair biological function with regard to immune response to recognizing and clearance of bacterial infection. Recent human microbiome studies suggest that the gut microbiome composition is differentiated in carriers of many risk variants of major CD susceptibility genes. This interplay between host genetics and its associated gut microbiome may play an essential role in the pathogenesis of CD. The ongoing microbiome research is aimed to investigate the detailed host genetics-microbiome interacting mechanism.

Keywords: Crohn disease; Gut microbiome; Host genetics.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

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