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. 1989 May;59(5):755-60.
doi: 10.1038/bjc.1989.158.

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

J S Burns  1 , L Lemoine, N R Lemoine, E D Williams, D Wynford-Thomas
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Free PMC article

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

J S Burns et al. Br J Cancer. 1989 May.
Free PMC article

Abstract

A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.

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