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. 1989:9 Suppl 9:73-7.
doi: 10.1111/J.1468-2982.1989.TB00076.X.

Early clinical experience with subcutaneous GR43175 in acute migraine: an overview

P Tfelt-Hansen  1 , J Brand, P Dano, A Doenicke, L J Findley, H K Iversen, D Melchart, H M Sahlender
Affiliations

Early clinical experience with subcutaneous GR43175 in acute migraine: an overview

P Tfelt-Hansen et al. Cephalalgia. 1989.

Abstract

In six European clinics 111 migraine patients were treated in a series of open dose-ranging studies with subcutaneous injections of 1 to 4 mg GR43175, a novel 5-HT 1-like receptor agonist. Response rates after 20-30 min were dose related and rose from 33% with 1 mg to 96% with 4 mg GR43175. Side effects were minor and transient. These promising results warrant confirmation in placebo-controlled double-blind trials. Migraine, treatment, 5-HT agonist, open studies.

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