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. 1989 Jul;171(7):3704-12.
doi: 10.1128/jb.171.7.3704-3712.1989.

Multiple defects in Escherichia coli mutants lacking HU protein

O Huisman  1 , M Faelen, D Girard, A Jaffé, A Toussaint, J Rouvière-Yaniv
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Multiple defects in Escherichia coli mutants lacking HU protein

O Huisman et al. J Bacteriol. 1989 Jul.

Abstract

The HU protein isolated from Escherichia coli, composed of two partially homologous subunits, alpha and beta, shares some of the properties of eucaryotic histones and is a major constituent of the bacterial nucleoid. We report here the construction of double mutants totally lacking both subunits of HU protein. These mutants exhibited poor growth and a perturbation of cell division, resulting in the formation of anucleate cells. In the absence of HU, phage Mu was unable to grow, to lysogenize, or to carry out transposition.

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References

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