Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jan;16(1):57-66.
doi: 10.1038/nrg3832. Epub 2014 Dec 2.

Spatially resolved transcriptomics and beyond

Nicola Crosetto  1 , Magda Bienko  1 , Alexander van Oudenaarden  2
Affiliations
Review

Spatially resolved transcriptomics and beyond

Nicola Crosetto et al. Nat Rev Genet. 2015 Jan.

Abstract

Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.

PubMed Disclaimer

References

    1. Curr Opin Genet Dev. 2011 Oct;21(5):630-7 - PubMed
    1. Nat Genet. 1998 Jul;19(3):225-32 - PubMed
    1. Nat Methods. 2006 Dec;3(12):995-1000 - PubMed
    1. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3940-5 - PubMed
    1. Nat Med. 2014 Apr;20(4):436-42 - PubMed

Publication types

MeSH terms

LinkOut - more resources