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. 2014 Dec 15;277(1-2):189-92.
doi: 10.1016/j.jneuroim.2014.09.021. Epub 2014 Oct 5.

Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study

Chiara Briani  1 , Chiara Dalla Torre  2 , Federica Lessi  3 , Tiziana Cavallaro  4 , Marina Scarlato  5 , Sergio Ferrari  4 , Marta Campagnolo  2 , Marta Lucchetta  2 , Ilaria Cabrini  4 , Michela Morbin  6 , Giuseppe Lauria  6 , Fausto Adami  3 , Angelo A Manfredi  7
Affiliations

Pentraxin-3 and VEGF in POEMS syndrome: a 2-year longitudinal study

Chiara Briani et al. J Neuroimmunol. .

Abstract

Circulating Pentraxin 3 (PTX3) and vascular endothelial growth factor (VEGF) levels were measured longitudinally (mean follow-up 2 years) by ELISA in 6 patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome and 16 controls. Expression of PTX3 was also assessed (immunohistochemistry) on sural nerve biopsies from POEMS and vasculitic neuropathy patients. No correlation was found between PTX3 and VEGF levels in POEMS or controls. Sural nerve biopsies from vasculitic neuropathy patients, but not those from POEMS syndrome, showed strong PTX3 staining. PTX3, expression of vessel inflammation/remodeling, and VEGF, crucial pro-angiogenic cytokine, appear to be independently regulated in POEMS syndrome.

Keywords: POEMS syndrome; Pentraxin 3; Polyneuropathy; Vascular endothelial growth factor (VEGF); Vasculitis.

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Comment in

  • Evaluation of pentraxin-3 in POEMS syndrome.
    Agilli M, Aydin FN. Agilli M, et al. J Neuroimmunol. 2015 Jan 15;278:136. doi: 10.1016/j.jneuroim.2014.12.015. Epub 2014 Dec 19. J Neuroimmunol. 2015. PMID: 25595262 No abstract available.

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