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Clinical Trial
. 1989 Jul;39(7):969-71.
doi: 10.1212/wnl.39.7.969.

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS

A J Thompson  1 , C Kennard, M Swash, B Summers, G M Yuill, D I Shepherd, S Roche, G D Perkin, L A Loizou, R Ferner, et al.
Affiliations
Clinical Trial

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS

A J Thompson et al. Neurology. 1989 Jul.

Abstract

To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.

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