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Clinical Trial
. 2015 Feb;166(2):257-61.e2.
doi: 10.1016/j.jpeds.2014.09.069. Epub 2014 Nov 12.

Retinopathy of prematurity risk prediction for infants with birth weight less than 1251 grams

Alex R Kemper  1 , Kelly C Wade  2 , Christoph P Hornik  3 , Gui-Shuang Ying  4 , Agnieshka Baumritter  5 , Graham E Quinn  5 ; Telemedicine Approaches to Evaluating Acute-phase Retinopathy of Prematurity (e-ROP) Study Cooperative Group
Collaborators, Affiliations
Clinical Trial

Retinopathy of prematurity risk prediction for infants with birth weight less than 1251 grams

Alex R Kemper et al. J Pediatr. 2015 Feb.

Abstract

Objective: To predict retinopathy of prematurity (ROP) exam findings among infants with birth weight <1251 g from 32-40 weeks postmenstrual age (PMA).

Study design: Secondary analysis of 3714 eye exams from 1239 infants.

Results: The likelihood of developing type 1 ROP by 40 weeks PMA varied by gestational age (GA) (P < .001), from 33% for ≤25 weeks, 10% for 26 or 27 weeks, 4% for 28 or 29 weeks, and none for ≥30 weeks. By 40 weeks PMA, 51% with GA ≤27 weeks still needed subsequent exams. Previous exam findings, GA, and PMA were predictive of the development of type 1 ROP (area under the curve, 0.78) or mature retina (area under the curve, 0.85).

Conclusions: This analysis provides the opportunity for development of an ROP approach to estimate resource needs in the neonatal intensive care unit and to facilitate communication with families when planning discharge or transfer.

Trial registration: ClinicalTrials.gov NCT01264276.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(online). The number of eye exams included in e-ROP by postmenstrual age (PMA) and gestational age (GA), in weeks.
Figure 2
Figure 2
The likelihood of developing Type 1 retinopathy of prematurity (ROP) over time, based on postmenstrual age (PMA) stratified by gestational age, in weeks. No cases of Type 1 ROP occurred in infants with GA ≥ 30 weeks.
Figure 3
Figure 3
The probability of mature retinal over time, based on post-menstrual age (PMA), stratified by gestational age (GA), in weeks.
Figure 4
Figure 4
The probability of needing follow-up (i.e., immature, mild ROP, or Type 2 ROP) over time, based on post-menstrual age (PMA), stratified by gestational age (GA).
See this image and copyright information in PMC

References

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