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Case Reports
. 2014 Dec:29:197-9.
doi: 10.1016/j.ijid.2014.07.014. Epub 2014 Oct 18.

Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia

Roger Dumke  1 , Simone Stolz  2 , Enno Jacobs  3 , Thomas Juretzek  4
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Free article
Case Reports

Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia

Roger Dumke et al. Int J Infect Dis. 2014 Dec.
Free article

Abstract

The development of macrolide resistance that occurred during 3 days of therapy with azithromycin to treat Mycoplasma pneumoniae pneumonia in a paediatric patient is reported. After extended molecular characterization of strains, the parallel occurrence of clones showing the non-mutated wild-type 23S rRNA sequence as well as mutations A2063G and A2064G, which are both responsible for phenotypic resistance, was confirmed for the first time.

Keywords: Community-acquired pneumonia; Mycoplasma pneumoniae; Typing Macrolide resistance.

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