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. 1989 May;47(2):191-6.
doi: 10.1016/0378-4274(89)90075-1.

Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein

J Abel  1 , N de Ruiter
Affiliations

Inhibition of hydroxyl-radical-generated DNA degradation by metallothionein

J Abel et al. Toxicol Lett. 1989 May.

Abstract

The effect of metallothionein (MT) on hydroxyl-radical-induced DNA damage was investigated in an in-vitro study. The degradation of DNA as demonstrated by agarose gel electrophoresis was inhibited by MT in a concentration-dependent manner. The degradation of DNA was almost completely inhibited by a concentration of 13 microM MT, whereas a concentration of 10 mM glutathione was needed to achieve the same protective effect.

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