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Review
. 2015 Mar;46(1):5-8.
doi: 10.1007/s12029-014-9667-y.

CNS involvement in pancreatic adenocarcinoma: a report of eight cases from the Johns Hopkins Hospital and review of literature

Abhijeet Kumar  1 , Meenakshi Dagar, Joseph Herman, Christine Iacobuzio-Donahue, Dan Laheru
Affiliations
Review

CNS involvement in pancreatic adenocarcinoma: a report of eight cases from the Johns Hopkins Hospital and review of literature

Abhijeet Kumar et al. J Gastrointest Cancer. 2015 Mar.

Abstract

Purpose: CNS metastasis of pancreatic cancer is extremely rare, although systemic metastasis is very common. We present eight such cases with various forms of nervous system involvement.

Methods: Data was gathered from chart review of 800 patients with pancreatic cancer treated between 2004 and 2012 of which eight patients are described with CNS metastases.

Results: The median age of patients was 61.5 years and the median time to develop CNS metastasis was 29 months. Interestingly, two patients had no other sites of metastasis. The treatment modalities tried included resection followed by radiation, resection alone, or whole brain radiation.

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Conflict of interest statement

Conflict of Interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Morphologic and molecular features of brain metastases. Shown are high-powered views of the primary carcinoma and matched brain metastasis that developed in this patient 1 year later. Both the primary and brain metastasis show strong positive nuclear labeling for TP53, indicating a genetic mutation in the TP53 gene, whereas labeling for SMAD4 is intact indicating the SMAD4 gene is wild type. All images, ×200
Fig. 2
Fig. 2
High right parasagittal parietal likely intra-axial enhancing mass, with moderate surrounding vasogenic edema. This image is of patient 2
Fig. 3
Fig. 3
Mass located along the anterior margin of vermis herniating into the fourth ventricle. Patient 6
Fig. 4
Fig. 4
Ring enhancing mass at the right caudate head with trace vasigenic edema. The image is of patient 6
See this image and copyright information in PMC

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