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Review
. 2014 Oct;21(4):151-3.
doi: 10.5214/ans.0972.7531.210408.

Ca(2+)- and CaMKII-mediated processes in early LTP

Lachlan A Byth  1
Affiliations
Review

Ca(2+)- and CaMKII-mediated processes in early LTP

Lachlan A Byth. Ann Neurosci. 2014 Oct.

Abstract

Learning methods determine the degree of stimulation of engrams encoding information to be memorised. More enriching modes of learning allow more enduring long-term potentiation of the synapses associated with these memories. The additional activity causes a prolonged increase in [Ca2+] in the dendritic spine of the postsynaptic neuron. This allows Ca(2+)-mediated molecular pathways to bring about cytoskeletal remodeling, posttranslational modifications, and protein trafficking. These processes contribute to early long-term potentiation of the synapses, strengthening the memory they store and lead to improved performance on tests of memory recall.

Keywords: AMPARs; Calcium signalling; Calcium/calmodulin-dependent protein kinase II; Long-term potentiation; Signal transduction.

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Figures

Fig. 1:
Fig. 1:
Simplified outline of CaMKII-mediated processes in early LTP.
See this image and copyright information in PMC

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