Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;9(1):203-206.
doi: 10.3892/etm.2014.2053. Epub 2014 Nov 6.

Expression of human DNA mismatch-repair protein, hMSH2, in patients with oral lichen planus

Hao-Bo Li  1 , Ying-Huai Zhang  1 , Hui-Zhen Chen  1 , Yong Chen  2
Affiliations

Expression of human DNA mismatch-repair protein, hMSH2, in patients with oral lichen planus

Hao-Bo Li et al. Exp Ther Med. 2015 Jan.

Abstract

hMSH2 is one of the human DNA mismatch repair genes that plays an important role in reducing mutations and maintaining genomic stability. The aim of the present study was to detect the expression and significance of hMSH2 protein in patients with oral lichen planus (OLP). The expression levels of hMSH2 in the OLP group (n=51) and control group with normal oral mucosa (NM; n=40) were detected using an immunohistochemical method and subsequently assessed. The positive rate of hMSH2 expression in the OLP group was 52.94%, while the rate was 80% in the control group, exhibiting a statistically significant difference (χ2=7.1993; P<0.05). However, the expression of hMSH2 in the OLP tissues was not shown to significantly correlate with the patient gender, age and type of OLP (P>0.05). In conclusion, the protein expression levels of hMSH2 in the OLP tissues were significantly reduced as compared with that in the NM tissues, indicating that hMSH2 plays a role in the development of OLP. Therefore, hMSH2 may be used as a biomarker for evaluating the cancer risk of patients with OLP.

Keywords: hMSH2; immunohistochemistry; mismatch repair genes; oral lichen planus.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Expression of hMSH2 in normal mucosa (SP; magnification, ×400).
Figure 2
Figure 2
Expression of hMSH2 in patients with oral lichen planus (SP; magnification, ×400).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Reenan RA, Kolodner RD. Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and Muts mismatch repair proteins. Genetics. 1992;132:963–973. - PMC - PubMed
    1. Fishel R, Lescoe MK, Rao MR, et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 1994;77:166. - PubMed
    1. Kunkel TA, Erie DA. DNA mismatch repair. Annu Rev Biochem. 2005;74:681–710. doi: 10.1146/annurev.biochem.74.082803.133243. - DOI - PubMed
    1. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 1995;332:305–311. doi: 10.1056/NEJM199502023320506. - DOI - PubMed
    1. Wagner A, Barrows A, Wijnen JT, et al. Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. Am J Hum Genet. 2003;72:1088–1100. doi: 10.1086/373963. - DOI - PMC - PubMed

LinkOut - more resources