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Review
. 2015 Feb;31(1):101-15, ix.
doi: 10.1016/j.cger.2014.08.021. Epub 2014 Nov 15.

Diabetes and cognition

Elizabeth Rose Mayeda  1 , Rachel A Whitmer  2 , Kristine Yaffe  3
Affiliations
Review

Diabetes and cognition

Elizabeth Rose Mayeda et al. Clin Geriatr Med. 2015 Feb.

Abstract

Dementia is a major cause of disability and death among older adults. Those with type 2 diabetes (T2D) are 50-100% more likely to develop dementia than those without T2D, but it is unknown whether this association reflects a causal relationship. Proposed mechanisms through which T2D could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of Alzheimer's disease and macrovascular and microvascular disorders in the brain. More research is needed to elucidate the link between T2D and dementia and identify strategies to maintain cognitive function among people with T2D.

Keywords: Aging; Cognition; Cognitive decline; Dementia; Epidemiology; Type 2 diabetes.

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Figures

Figure 1
Figure 1. Figure illustrating potential causal links between type 2 diabetes and cognitive decline and dementia
See this image and copyright information in PMC

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