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Review
. 2015 Mar:64:137-43.
doi: 10.1016/j.jcv.2014.08.029. Epub 2014 Oct 22.

Recent advances in research on Crimean-Congo hemorrhagic fever

Anna Papa  1 , Ali Mirazimi  2 , Iftihar Köksal  3 , Augustin Estrada-Pena  4 , Heinz Feldmann  5
Affiliations
Review

Recent advances in research on Crimean-Congo hemorrhagic fever

Anna Papa et al. J Clin Virol. 2015 Mar.

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities.

Keywords: Crimean-Congo hemorrhagic fever; Ecology; Epidemiology.

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Figures

Figure 1
Figure 1
Tick on the back of a patient.
Figure 2
Figure 2
A patient with Crimean-Congo hemorrhagic fever presenting ecchymosis on the right lower extremity and the pelvic area.
Figure 3
Figure 3
Algorithm of CCHF case management.
See this image and copyright information in PMC

References

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