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Review
. 2014 Dec;35(4):781-95.
doi: 10.1016/j.ccm.2014.08.014. Epub 2014 Sep 24.

Steroids for acute respiratory distress syndrome?

Catherine L Hough  1
Affiliations
Review

Steroids for acute respiratory distress syndrome?

Catherine L Hough. Clin Chest Med. 2014 Dec.

Erratum in

  • Clin Chest Med. 2015 Mar;36(1):xiii

Abstract

The development and severity of acute respiratory distress syndrome (ARDS) are closely related to dysregulated inflammation, and the duration of ARDS and eventual outcomes are related to persistent inflammation and abnormal fibroproliferation. Corticosteroids are potent modulators of inflammation and inhibitors of fibrosis that have been used since the first description of ARDS in attempts to improve outcomes. There is no evidence that corticosteroids prevent the development of ARDS among patients at risk. High-dose and short-course treatment with steroids does not improve the outcomes of patients with ARDS. Additional studies are needed to recommend treatment with steroids for ARDS.

Keywords: ARDS; Corticosteroids; Outcomes; Prevention; Treatment.

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