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. 1978 Mar 1;56(2):163-6.
doi: 10.1007/BF00431843.

The effect of chronic lithium administration on dopamine metabolism in rat striatum

J E Hesketh, N M Nicolaou, G W Arbuthnott, A K Wright

The effect of chronic lithium administration on dopamine metabolism in rat striatum

J E Hesketh et al. Psychopharmacology (Berl). .

Abstract

Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentration after 3 weeks of lithium administration. There was no change in tyrosine hydroxylase activity after 1, 2, and 3 weeks treatment. The results indicate an increase in the release and turnover of dopamine in the lithium-treated animals.

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References

    1. Eur J Pharmacol. 1976 Mar;36(1):163-71 - PubMed
    1. J Pharmacol Exp Ther. 1971 Aug;178(2):325-30 - PubMed
    1. Biochem Soc Trans. 1976;4(2):328-30 - PubMed
    1. Nature. 1973 Jun 29;243(5409):520-1 - PubMed
    1. Science. 1973 Feb 2;179(4072):441-6 - PubMed

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