Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Dec 1;24(23):5512-5.
doi: 10.1016/j.bmcl.2014.10.004. Epub 2014 Oct 13.

A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the x(C)⁻ transporter

Hua Yang  1 , Qing Miao  1 , Bruce F Johnson  2 , Michael J Rishel  2 , Vesna Sossi  3 , Katherine Dinelle  3 , François Bénard  4 , Donald T Yapp  5 , Jack M Webster  2 , Paul Schaffer  6
Affiliations

A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the x(C)⁻ transporter

Hua Yang et al. Bioorg Med Chem Lett. .

Abstract

Oxidative stress has been implicated in a variety of conditions, including cancer, heart failure, diabetes, neurodegeneration and other diseases. A potential biomarker for oxidative stress is the cystine/glutamate transporter, system x(C)(-). L-Aminosuberic acid (L-ASu) has been identified as a system x(C)(-) substrate. Here we report a facile method for [(11)C]N-Me labeling of L-ASu, automation of the radiochemical process, and preliminary PET imaging with EL4 tumor bearing mice. The results demonstrate uptake in the tumor above background, warranting further studies on the use of radiolabeled analogs of L-ASu as a PET imaging agent for system x(C)(-).

Keywords: C-11; Cystine transporter; N-methylation; Oxidative stress; Radiolabelling.

PubMed Disclaimer

Substances

LinkOut - more resources