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Comment
. 2014 Nov 24;31(4):387-9.
doi: 10.1016/j.devcel.2014.11.008. Epub 2014 Nov 24.

Arrested detachment: a DEPDC1B-mediated de-adhesion mitotic checkpoint

Rafael Garcia-Mata  1
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Arrested detachment: a DEPDC1B-mediated de-adhesion mitotic checkpoint

Rafael Garcia-Mata. Dev Cell. .
Free article

Abstract

Mitotic cell rounding is accompanied by changes in the actin cytoskeleton, de-adhesion, and an increase in cortical rigidity. In this issue, Marchesi et al. (2014) describe an adhesion-dependent mitotic checkpoint and identify DEPDC1B as the factor responsible for coordinating de-adhesion with the ability of cells to enter mitosis.

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