HORMA domains at the heart of meiotic chromosome dynamics
- PMID: 25458007
- DOI: 10.1016/j.devcel.2014.11.009
HORMA domains at the heart of meiotic chromosome dynamics
Abstract
HORMA domain proteins are required for the careful orchestration of chromosomal organization during meiosis. Kim et al. (2014) and Silva et al. (2014) now provide structural and functional insights into the roles of C. elegans HORMA proteins, revealing parallels to the function of the HORMA protein MAD2 in mitotic checkpoint signaling.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.Dev Cell. 2014 Nov 24;31(4):487-502. doi: 10.1016/j.devcel.2014.09.013. Epub 2014 Nov 6. Dev Cell. 2014. PMID: 25446517 Free PMC article.
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The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.Dev Cell. 2014 Nov 24;31(4):503-11. doi: 10.1016/j.devcel.2014.10.001. Epub 2014 Nov 6. Dev Cell. 2014. PMID: 25455309
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