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Review
. 2015 Mar:188:82-5.
doi: 10.1016/j.autneu.2014.10.017. Epub 2014 Oct 23.

Autonomic dysfunction in multiple sclerosis: implications for exercise

Mu Huang  1 , Ollie Jay  2 , Scott L Davis  3
Affiliations
Review

Autonomic dysfunction in multiple sclerosis: implications for exercise

Mu Huang et al. Auton Neurosci. 2015 Mar.

Abstract

Multiple sclerosis (MS), a progressive neurological disease, can result in autonomic dysfunction. Impairments in the autonomic control of cardiovascular and thermoregulatory function during exercise have been observed in MS. Attenuated elevations in blood pressure during exercise in MS patients can negatively impact blood flow to skeletal muscle. Diminished sweating during exercise may impair heat dissipation likely limiting the exercise intensity that can be performed before detrimental core temperatures are reached. Further understanding the physiologic mechanisms of autonomic dysfunction during exercise in MS may lead to the development of novel therapeutic strategies targeted at improving quality of life in individuals with this disease.

Keywords: Blood pressure; Cardiovascular; Demyelination; Sweat; Sympathetic nerve activity; Thermoregulation.

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References

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