Response to pathological processes in the peritoneal cavity--sepsis, tumours, adhesions, and ascites

Abstract

The peritoneum is one of the commonest sites for pathological processes in pediatric surgery. Its response to pathological processes is characterized by an inflammatory reaction with specific pathways depending on the type of injury or peritoneal process involved. This review discusses the current understanding of peritoneal inflammation, adhesion formation, intra-abdominal sepsis, peritoneal metastasis, and ascites and briefly reviews new therapeutic strategies to treat or prevent these pathological entities. Recent studies have improved the understanding of peritoneal responses, resulting in possible new targets for prevention and therapy.

Keywords: Adhesions; Ascites; Inflammatory response; Peritoneal metastasis; Peritoneum; Sepsis.