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. 2014 Nov;7(11):1175-7.
doi: 10.1016/j.jcmg.2014.04.024. Epub 2014 Nov 10.

Cardiac steatosis and left ventricular dysfunction in HIV-infected patients treated with highly active antiretroviral therapy

Michael D Nelson, Lidia S Szczepaniak, Troy M LaBounty, Edward Szczepaniak, Debiao Li, Mourad Tighiouart, Quanlin Li, Rohan Dharmakumar, Gregg Sannes, Zhaoyang Fan, Roya Yumul, W David Hardy, Antonio Hernandez Conte

Cardiac steatosis and left ventricular dysfunction in HIV-infected patients treated with highly active antiretroviral therapy

Michael D Nelson et al. JACC Cardiovasc Imaging. 2014 Nov.
No abstract available

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Figures

FIGURE 1
FIGURE 1. Ectopic Fat Deposition and LV Dysfunction in HIV-Infected Patients Receiving HAART
(A) Representative illustration of a typical cardiac magnetic resonance (CMR) image, showing all 4 chambers of the heart. The white box over the intraventricular septum illustrates the voxel position during spectroscopy. The green line illustrates a representative cardiac spectra, showing a large area of resonance for myocardial water and a small area of resonance for myocardial triglyceride content; magnified directly above for a representative human immunodeficiency virus (HIV)-positive (+) subject (pink line) and a representative HIV-negative (−) subject (green line). The summary data demonstrate a 3-fold elevation in myocardial triglyceride content in HIV-positive subjects (pink bar) versus well-matched HIV-negative control subjects (green bar). (B, i to iv) Representative illustration of a mid-short-axis image of the LV, with tissue tagging applied at end diastole (i) and progressing to end systole (iv). The graph shows the circumferential strain from a representative HIV-positive subject (pink line) and control subject (green line). The summary data demonstrate impaired circumferential strain in cases versus control subjects. (C, i to iv) Representative illustration of a mid-short-axis image of the left ventricle, with tissue tagging applied at end systole (i), progressing to diastasis (iv). The graph represents the diastolic circumferential strain rate from a representative HIV-positive subject (pink line) and a control subject (green line). Time 0 represents end systole. The dashed line indicates the rate of ventricular relaxation. The summary data show impaired diastolic strain rate in cases versus control subjects. Data are presented as mean ± SE. HAART = highly active antiretroviral therapy; 1H MRS = hydrogen ion magnetic resonance spectroscopy.
See this image and copyright information in PMC

References

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