Increased incidence of pelvic organ prolapse in women with acromegaly

Abstract

Objective: To evaluate gynecological problems of female patients with acromegaly and the relationship of these problems with the activity of the disease.

Study design: Thirty-four women with acromegaly and 27 age- and body mass index-matched female healthy controls (HC) were included in the study. Demographic features, medical history, hormonal status and disease activity were obtained. A detailed gynecological examination was performed.

Results: The incidence of pelvic organ prolapse (POP) was higher in patients with acromegaly (53%, n=18) compared to the HC (15%, n=4) (p=0.003). Limiting the analysis to only cases with previous pregnancy, POP was seen in 18 (60%) of 30 cases with acromegaly and in 4 (20%) of 20 of the HC (p=0.005). Additionally, in cases with prior vaginal delivery, POP was present in 18 (60%) of 30 cases with acromegaly and in 4 (24%) of 17 of the HC (p=0.02). The frequency of POP was similar in patients with controlled and uncontrolled acromegaly (p=0.3).

Conclusion: Acromegaly may facilitate occurrence of pelvic organ prolapse and may cause additional health issues in female cases.

Keywords: Acromegaly; Fertility; Gynecological problems; Pelvic organ prolapse; Pregnancy.