Very-low-field MRI of laser polarized xenon-129

Abstract

We describe a homebuilt MRI system for imaging laser-polarized xenon-129 at a very low holding field of 2.2mT. A unique feature of this system was the use of Maxwell coils oriented at so-called "magic angles" to generate the transverse magnetic field gradients, which provided a simple alternative to Golay coils. We used this system to image a laser-polarized xenon-129 phantom with both a conventional gradient-echo and a fully phase-encoded pulse sequence. In other contexts, a fully phase-encoded acquisition, also known as single-point or constant-time imaging, has been used to enable distortion-free imaging of short-T₂^∗ species. Here we used this technique to overcome imperfections associated with our homebuilt MRI system while also taking full advantage of the long T₂^∗ available at very low field. Our results demonstrate that xenon-129 image quality can be dramatically improved at low field by combining a fully phase-encoded k-space acquisition with auxiliary measurements of system imperfections including B₀ field drift and gradient infidelity.

Keywords: Gradient coils; Hyperpolarized xenon-129; Low field MRI; Pulse sequences.