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. 2015 Jan:196:185-93.
doi: 10.1016/j.envpol.2014.09.020.

Influence of titanium dioxide nanoparticles on 2,3,7,8-tetrachlorodibenzo-p-dioxin bioconcentration and toxicity in the marine fish European sea bass (Dicentrarchus labrax)

Camilla Della Torre  1 , Francesco Buonocore, Giada Frenzilli, Simonetta Corsolini, Andrea Brunelli, Patrizia Guidi, Anton Kocan, Michela Mariottini, Filomena Mottola, Marco Nigro, Karla Pozo, Elisa Randelli, Maria Luisa Vannuccini, Simona Picchietti, Marianna Santonastaso, Vittoria Scarcelli, Silvano Focardi, Antonio Marcomini, Lucia Rocco, Giuseppe Scapigliati, Ilaria Corsi
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Free article

Influence of titanium dioxide nanoparticles on 2,3,7,8-tetrachlorodibenzo-p-dioxin bioconcentration and toxicity in the marine fish European sea bass (Dicentrarchus labrax)

Camilla Della Torre et al. Environ Pollut. 2015 Jan.
Free article

Abstract

The present study investigated the influence of nano-TiO(2) (1 mg L(-1)) on 2,3,7,8-tetrachlorodibenzo-p-dioxin(2,3,7,8-TCDD) (46 pg L(-1)) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nano-TiO2 and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW.

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