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. 1989 May;33(5):714-6.
doi: 10.1128/AAC.33.5.714.

Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection

S C Harris  1 , J E Wallace, G Foulds, M G Rinaldi
Affiliations

Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection

S C Harris et al. Antimicrob Agents Chemother. 1989 May.

Abstract

A megabore column gas-liquid chromatographic method which uses nitrogen-phosphorus detection was developed for the analysis of fluconazole in plasma, serum, cerebrospinal fluid, or urine. The assay was linear from 0.2 to 200 micrograms/ml and had an average coefficient of variation of 7%. The suitability of the assay for pharmacokinetic studies was demonstrated.

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