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Randomized Controlled Trial
. 2015 Jan 15;115(2):196-201.
doi: 10.1016/j.amjcard.2014.10.022. Epub 2014 Oct 29.

Effect of omega-three polyunsaturated fatty acids on inflammation, oxidative stress, and recurrence of atrial fibrillation

Charles Vanderbilt  1 , Marcia Free  1 , Jie Li  1 , Tebeb Gebretsadik  2 , Aihua Bian  2 , Ayumi Shintani  2 , Brian F McBride  1 , Joseph Solus  1 , Ginger Milne  1 , George H Crossley  3 , David Thompson  4 , Humberto Vidaillet  5 , Henry Okafor  6 , Dawood Darbar  7 , Katherine T Murray  7 , C Michael Stein  8
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Randomized Controlled Trial

Effect of omega-three polyunsaturated fatty acids on inflammation, oxidative stress, and recurrence of atrial fibrillation

Charles Vanderbilt et al. Am J Cardiol. .

Abstract

The efficacy of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in preventing recurrence of atrial fibrillation (AF) is controversial and their effects on inflammation and oxidative stress in this population are not known. This study examined the effects of high-dose marine n-3 PUFAs added to conventional therapy on the recurrence of AF and on markers of inflammation and oxidative stress. Patients with paroxysmal or persistent AF were randomized to n-3 PUFAs (4 g/day; n = 126) or placebo (n = 64) in a 2:1 ratio in a prospective, double-blind, placebo-controlled, parallel group study. The primary outcome was time to recurrence of AF. Secondary outcomes were changes in biomarkers of inflammation (serum interleukin [IL]-6, IL-8, IL-10, tissue necrosis factor alpha, monocyte chemoattractant protein-1, and vascular endothelial growth factor), N-terminal-pro-brain-type natriuretic peptide, and oxidative stress (urinary F2-isoprostanes). AF recurred in 74 patients (58.7%) randomized to n-3 PUFAs and in 30 patients (46.9%) who received placebo; time to recurrence of AF did not differ significantly in the 2 groups (hazard ratio 1.20; 95% confidence interval 0.76 to 1.90, adjusted p = 0.438). Compared with placebo, n-3 PUFAs did not result in clinically meaningful changes in concentrations of inflammatory markers, N-terminal-pro-brain-type natriuretic peptide or F2-isoprostanes. In conclusion, in patients with paroxysmal or persistent AF, treatment with n-3 PUFAs 4 g/day did not reduce the recurrence of AF, nor was it associated with clinically important effects on concentrations of markers of inflammation and oxidative stress. (Clinical trial registration number, NCT 00552084.).

Trial registration: ClinicalTrials.gov NCT00552084.

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Figures

Figure 1
Figure 1
Study flowchart
Figure 2
Figure 2. Time to recurrence of atrial fibrillation
There was no statistically significant difference in time to recurrence of atrial fibrillation among patients randomized to receive n3-PUFAs and those who received placebo (hazard ratio 1.20; 95% CI 0.79 - 1.84; P=0.393 unadjusted and after adjustment for age, race, sex, randomization stratum, coronary artery disease, congestive heart failure and duration of atrial fibrillation HR: 1.20; 95% CI 0.76 - 1.90; P=0.438).
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References

    1. Leaf A, Kang JX, Xiao YF, Billman GE. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003;107:2646–2652. - PubMed
    1. Kang JX, Leaf A. Antiarrhythmic effects of polyunsaturated fatty acids. Recent studies. Circulation. 1996;94:1774–1780. - PubMed
    1. Das UN. Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how? Prostaglandins Leukot Essent Fatty Acids. 2000;63:351–362. - PubMed
    1. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW, Cannon JG, Rogers TS, Klempner MS, Weber PC. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med. 1989;320:265–271. - PubMed
    1. Higdon JV, Liu J, Du SH, Morrow JD, Ames BN, Wander RC. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. Am J Clin Nutr. 2000;72:714–722. - PubMed

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