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Comment
. 2014 Dec 2;107(11):2484-5.
doi: 10.1016/j.bpj.2014.10.047. Epub 2014 Dec 2.

Switching from protease-independent to protease-dependent cancer cell invasion

Lijuan He  1 , Denis Wirtz  2
Affiliations
Comment

Switching from protease-independent to protease-dependent cancer cell invasion

Lijuan He et al. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Illustrative figure showing two modes of cancer cell invasion. (A) Protease-independent invasion occurs when the traction stress of the matrix generated by cell invasion is small (<165 Pa for MDA-MB-231 cells in Matrigel in this study by Aung et al.). The invading cell exhibits membrane blebs at the leading edge, where there is no MT1-MMP. (B) The cell switches to protease-dependent invasion when the traction stress increases (to >165 Pa for MDA-MB-231 cells in Matrigel in the work by Aung et al.) and develops invadopodia-like protrusions that are rich in MT1-MMP. Actin is shown in green and MT1-MMP in red. To see this figure in color, go online.
See this image and copyright information in PMC

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References

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