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. 2015 Jan;3(1):13-17.
doi: 10.3892/mco.2014.429. Epub 2014 Sep 25.

Long non-coding RNAs and hepatocellular carcinoma

Fu-Jun Yu  1 , Jian-Jian Zheng  2 , Pei-Hong Dong  3 , Xiao-Ming Fan  1
Affiliations

Long non-coding RNAs and hepatocellular carcinoma

Fu-Jun Yu et al. Mol Clin Oncol. 2015 Jan.

Abstract

Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post-transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets.

Keywords: H19; HOX antisense intergenic RNA; downregulated expression by HBx; hepatocellular carcinoma; high expression in HCC; highly upregulated in liver cancer; long non-coding RNA; maternally expressed gene 3; metastasis associated lung adenocarcinoma transcript 1; microvascular invasion in HCC.

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