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. 2015 Jan 19;54(4):1270-4.
doi: 10.1002/anie.201409617. Epub 2014 Dec 2.

A general synthesis of fluoroalkylated alkenes by palladium-catalyzed Heck-type reaction of fluoroalkyl bromides

Zhang Feng  1 , Qiao-Qiao Min, Hai-Yang Zhao, Ji-Wei Gu, Xingang Zhang
Affiliations

A general synthesis of fluoroalkylated alkenes by palladium-catalyzed Heck-type reaction of fluoroalkyl bromides

Zhang Feng et al. Angew Chem Int Ed Engl. .

Abstract

An efficient palladium-catalyzed Heck-type reaction of fluoroalkyl halides, including perfluoroalkyl bromides, trifluoromethyl iodides, and difluoroalkyl bromides, has been developed. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, and provides a general and straightforward access to fluoroalkylated alkenes which are of interest in life and material sciences.

Keywords: alkenes; fluoroalkylation; halides; palladium; synthetic methods.

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