Enteroendocrine MC4R and energy balance: linking the long and the short of it

Sean Manning¹, Rachel L Batterham²

Affiliations

¹ Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; School of Medicine, University College Cork, Cork, Ireland.
² Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; UCLH Centre for Weight Loss, Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK. Electronic address: r.batterham@ucl.ac.uk.

PMID: 25470541
DOI: 10.1016/j.cmet.2014.11.014

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Enteroendocrine MC4R and energy balance: linking the long and the short of it

Sean Manning et al. Cell Metab. 2014.

Free article

. 2014 Dec 2;20(6):929-31.

doi: 10.1016/j.cmet.2014.11.014.

Authors

Sean Manning¹, Rachel L Batterham²

Affiliations

¹ Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; School of Medicine, University College Cork, Cork, Ireland.
² Centre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; UCLH Centre for Weight Loss, Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK. Electronic address: r.batterham@ucl.ac.uk.

PMID: 25470541
DOI: 10.1016/j.cmet.2014.11.014

Abstract

Central MC4R pathways are well established as integrators of peripheral signals in the control of energy balance. In this issue, Panaro et al. (2014) identify that MC4Rs expressed on intestinal enteroendocrine L cells regulate PYY and GLP-1 secretion, two gut hormones implicated in the regulation of energy and glucose homeostasis.

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The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD. Panaro BL, et al. Cell Metab. 2014 Dec 2;20(6):1018-29. doi: 10.1016/j.cmet.2014.10.004. Epub 2014 Nov 20. Cell Metab. 2014. PMID: 25453189 Free PMC article.

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Enteroendocrine MC4R and energy balance: linking the long and the short of it

Affiliations

Enteroendocrine MC4R and energy balance: linking the long and the short of it

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Abstract

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