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Multicenter Study
. 2014 Dec 3;9(12):e114192.
doi: 10.1371/journal.pone.0114192. eCollection 2014.

Micronutrient levels and supplement intake in pregnancy after bariatric surgery: a prospective cohort study

Roland Devlieger  1 , Isabelle Guelinckx  2 , Goele Jans  3 , Willy Voets  4 , Caroline Vanholsbeke  5 , Greet Vansant  2
Affiliations
Multicenter Study

Micronutrient levels and supplement intake in pregnancy after bariatric surgery: a prospective cohort study

Roland Devlieger et al. PLoS One. .

Abstract

Background: Studies report frequent micronutrient deficiencies after bariatric surgery, but less is known about micronutrient levels of pregnant women after bariatric surgery.

Objective: To prospectively evaluate micronutrient levels and supplement intake in pregnancy following bariatric surgery.

Design: A multicenter prospective cohort study including women with restrictive or malabsorptive types of bariatric surgery. Nutritional deficiencies, together with supplement intake, were screened during pregnancy.

Results: The total population included 18 women in the restrictive and 31 in the malabsorptive group. Most micronutrients were depleted and declined significantly during pregnancy. The proportion of women with low vitamin A and B-1 levels increased to respectively 58 and 17% at delivery (P = 0.005 and 0.002). The proportion of women with vitamin D deficiency decreased from 14% at trimester 1 to 6% at delivery (P = 0.030). Mild anemia was found in respectively 22 and 40% of the women at trimester 1 and delivery. In the first trimester, most women took a multivitamin (57.1%). In the second and third trimester, the majority took additional supplements (69.4 and 73.5%). No associations were found between supplement intake and micronutrient deficiencies.

Conclusion: Pregnant women with bariatric surgery show frequent low micronutrient levels. Supplementation partially normalizes low levels of micronutrients.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Mean (±SD) concentrations of various markers of nutritional/health status.
light grey = malabsorptive group. dark grey = restrictive group. 1 = significant time effect. 2 = significant group effect. 3 = significant time x group effect.
See this image and copyright information in PMC

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