Hypoglycaemia and CV risk: Perceptions and reality

Abstract

Hypoglycemia is an established complication of diabetes management. It has been related to numerous adverse outcomes including dementia, falls, cognitive dysfunction, coma, cardiovascular and cerebrovascular events and many more. Of all these adverse cardiovascular outcomes is the most discussed and reported complication related to hypoglycemia. There have been several mechanistic case reports and retrospective data linking hypoglycemia with adverse CVD outcomes. However, hard-core cause and effect relationship remains elusive. This review looks into the available data and where we stand as of now on this issue of hypoglycemia and adverse CVD outcomes.

Keywords: CV risk; Hypoglycemia; Mortality; Trials; Type 2 diabetes mellitus.