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. 2015 Jan 25;51(7):1244-7.
doi: 10.1039/c4cc08702j.

Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes

Fei Wu  1 , Lindsey N Pelster, Shelley D Minteer
Affiliations

Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes

Fei Wu et al. Chem Commun (Camb). .

Abstract

Dynamics of metabolon formation in mitochondria was probed by studying diffusional motion of two sequential Krebs cycle enzymes in a microfluidic channel. Enhanced directional co-diffusion of both enzymes against a substrate concentration gradient was observed in the presence of intermediate generation. This reveals a metabolite directed compartmentation of metabolic pathways.

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