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Clinical Trial
. 2014 Nov;29 Suppl 3(Suppl 3):S201-9.
doi: 10.3346/jkms.2014.29.S3.S201. Epub 2014 Nov 21.

A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow's feet: a new concept of regenerative filler

Chang Sik Pak  1 , Jongho Lee  1 , Hobin Lee  1 , Jaehoon Jeong  1 , Eun-Hee Kim  1 , Jinwook Jeong  1 , Hyeyeon Choi  1 , Byunghwi Kim  1 , Sujin Oh  2 , Iksoo Kim  3 , Chan Yeong Heo  1
Affiliations
Clinical Trial

A phase III, randomized, double-blind, matched-pairs, active-controlled clinical trial and preclinical animal study to compare the durability, efficacy and safety between polynucleotide filler and hyaluronic acid filler in the correction of crow's feet: a new concept of regenerative filler

Chang Sik Pak et al. J Korean Med Sci. 2014 Nov.

Abstract

The Rejuran® is a new filler product made from purified polynucleotides. Here we present data from an animal study and a clinical trial to examine the durability, efficacy and safety of the Rejuran® on crow's feet. For the animal study, 25 mice were divided into three groups: Group 1 received phosphate buffered saline (PBS); Group 2 were treated with Yvoire®; and Group 3 were treated with Rejuran®. The durability and efficacy of each treatment were assessed by microscopy and staining. In the clinical trial, 72 patients were randomized to receive Rejuran® treatment for crow's feet on one side and Yvoire-Hydro® on the contralateral side, at a ratio of 1:1. Repeated treatments were performed every two weeks for a total of three times, over a total of 12 weeks' observation. All injections and observations of efficacy and safety were performed by the same two investigators. In the animal study, the Rejuran® group showed similar durability and inflammatory response to the Yvoire® group. Upon efficacy assessment, the Rejuran® group showed the greatest elasticity and collagen composition, and a significant difference in skin surface roughness and wrinkle depth. In the clinical trial, the primary and secondary objective efficacy outcome measure showed no statistical significance between the two groups, and in safety outcomes there were no unexpected adverse effects. Our data suggest that the Rejuran®, as a new regenerative filler, can be useful to reduce wrinkles, by showing evidence for its efficacy and safety.

Keywords: Polydeoxyribonucleotides; Polynucleotides; Rejuvenation; Wound Healing.

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Conflict of interest statement

We certify that all authors of this manuscript have had no financial involvement (e.g. employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, and royalties) within the past five years, or will have in the foreseeable future, with any organization or entity with a financial interest in, or financial conflict with, the subject matter or materials discussed in the manuscript.

Figures

Fig. 1
Fig. 1
Study flowchart.
Fig. 2
Fig. 2
Tissue elasticity in the animal study.
Fig. 3
Fig. 3
Skin surface roughness in the animal study.
Fig. 4
Fig. 4
Maximal wrinkle depth in the animal study.
Fig. 5
Fig. 5
Van Gieson staining in the animal study.
See this image and copyright information in PMC

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