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Case Reports
. 2014 Dec;26(6):747-50.
doi: 10.5021/ad.2014.26.6.747. Epub 2014 Nov 26.

Pigmented mammary paget disease misdiagnosed as malignant melanoma

Ji Hye Lee  1 , Tae Hyung Kim  1 , Soo-Chan Kim  1 , You Chan Kim  2 , Mi Ryung Roh  1
Affiliations
Case Reports

Pigmented mammary paget disease misdiagnosed as malignant melanoma

Ji Hye Lee et al. Ann Dermatol. 2014 Dec.

Abstract

Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma.

Keywords: Malignant melanoma; Mammary paget disease.

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Figures

Fig. 1
Fig. 1
Clinical and dermoscopic features of pigmented mammary Paget disease. (A) Well-demarcated dark brown plaque on the nipple. (B) Dermoscopy shows irregular dots/globules, gray-blue pepper-like granules, and a scar-like appearance.
Fig. 2
Fig. 2
Histologic and immunohistochemical features of pigmented mammary Paget disease. (A) Initial biopsy specimen showing large neoplastic epithelial cells with pigmentation and dermal melanophages (H&E, ×400). (B) Excision specimen showing intraepidermal proliferation of atypical cells with large hyperchromatic nuclei and pale cytoplasm (H&E, ×400). Tumor cells express immunoreactivity for (C) cytokeratin 7 (CK7, ×100) and (D) C-erbB2 (×100). Tumor cells show negative immunoreactivity for (E) HMB45 (×100) and (F) Melan-A (×100).
See this image and copyright information in PMC

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